Alice (Milla Jovovich), now in hiding in the Nevada desert, once again joins forces with Carlos Olivera and L.J., along with new survivors Claire, K-Mart and Nurse Betty to try to eliminate the deadly virus that threatens to make every human being undead...and to seek justice. Since being captured by the Umbrella Corporation, Alice has been subjected to biogenic experimentation and becomes genetically altered, with super-human strengths, senses and dexterity. These skills, and more, will be needed if anyone is to remain alive.